Protein Evolution & Design
De novo design with state-of-the-art and custom in-house tools. Evolution-based approaches including ancestral sequence reconstruction. Stabilisation, biosensors, and expression optimisation.
Protein Production & Purification
Expression system optimisation, scale-up from bench to fermenter, purification workflow design, and contract manufacturer evaluation for academic and biotech applications.
Protein Characterisation
Biophysical characterisation (ITC, SPR, DSF), structural characterisation (X-ray crystallography, cryo-EM), and computational modelling (AlphaFold, molecular dynamics).
Scientific Consulting
Scientific strategy, AI-readiness assessments, and translating complex science into actionable plans for biotech.
My work has been published in:
Nature Chemical Biology ·
Nature Communications ·
PNAS ·
Cell Reports ·
Nature Machine Intelligence
Recent Publications
- Kaczmarski J, Jackson CJ, Cockburn IA. Having your cake and eating it too – a new target for sporozoite-neutralising mAbs. Trends in Parasitology, 2025
- Gall B, Pulsford SB, Matthews D, Spence MA, Kaczmarski J, Chen JZ, Sandhu M, Stone E, Nichols J, Jackson CJ. Protein Evolution as a Complex System. Nature Chemical Biology, 2025
- Matthews DS, Spence M, Mater AC, Nichols J, Pulsford SB, Sandhu M, Kaczmarski J, Miton C, Tokuriki N, Jackson C. Leveraging ancestral sequence reconstruction for protein representation learning. Nature Machine Intelligence, 2024
- Spence MA, Kaczmarski JA, Saunders JW, Jackson CJ. Ancestral sequence reconstruction for protein engineers. Current Opinion in Structural Biology, 2021
- Kaczmarski JA, Mahawaththa MC, Feintuch A, Clifton BE, Adams LA, Goldfarb D, Otting G, Jackson CJ. Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme. Nature Communications, 2020
- Clifton BE, Kaczmarski JA, Carr PD, Gerth ML, Tokuriki N, Jackson CJ. Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein. Nature Chemical Biology, 2018
Interested in working together?
Work with me →